News

New Publication!

I'm excited to share that our group has recently published a new paper in the Journal of Organic Chemistry titled "Dynamically Generated Carbenium Species via Photoisomerization of Cyclic Alkenes: Mild Friedel–Crafts Alkylation." This work demonstrates how light can be used to dynamically drive carbenium ion formation and that this can be used to accomplish very mild Friedel-Crafts reaction and makes access to 1,1-diaryl quaternary centers on 6-membered rings. The reaction can be used to quickly access libraries of 4,4-diaryl piperidines in a single step by coupling them with arenes, providing expedited access to this medicinally relevant motif. Check out the research by Timothy Schoch, Osaid Alkhamayseh, Nathan Herndon, Erik Lantz, and Tyler Fleske! https://doi.org/10.1021/acs.joc.5c00061